Helenalin

Helenalin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17050-1 1 mg -

6 - 10 business days*

675.00€
 
Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has... more
Product information "Helenalin"
Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-kappaB at doses from 1 to 20 µM. Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-kappaB. It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-kappaB. Helenalin has antibacterial and anti-protozoal activities.Formal Name: 3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione. CAS Number: 6754-13-8. Synonyms: NSC 85236. Molecular Formula: C15H18O4. Formula Weight: 262.3. Purity: >98%. Formulation: (Request formulation change), A powder. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 223 nm. SMILES: O[C@H]1[C@@](C(C(O2)=O)=C)([H])[C@@]2([H])C[C@@H](C)[C@@](C=C3)([H])[C@@]1(C)C3=O. InChi Code: InChI=1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1. InChi Key: ZVLOPMNVFLSSAA-XEPQRQSNSA-N.
Keywords: NSC 85236, 3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione
Supplier: Cayman Chemical
Supplier-Nr: 17050

Properties

Application: Antiinflammatory, NF-kappaB mediated gene expression inhibitor
MW: 262.3 D
Formula: C15H18O4
Purity: >98%
Format: Solid

Database Information

CAS : 6754-13-8| Matching products
KEGG ID : K04735 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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Helenalin Helenalin
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