Gypenoside XVII

Gypenoside XVII
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay34514-1 1 mg -

6 - 10 business days*

84.00€
Cay34514-5 5 mg -

6 - 10 business days*

283.00€
Cay34514-10 10 mg -

6 - 10 business days*

520.00€
Cay34514-25 25 mg -

6 - 10 business days*

1,196.00€
 
Gypenoside XVII is a saponin that has been found in P. notoginseng and has diverse biological... more
Product information "Gypenoside XVII"
Gypenoside XVII is a saponin that has been found in P. notoginseng and has diverse biological activities. It induces autophagic clearance of amyloid-beta precursor protein (APP), Abeta40, and Abeta42 in PC12 cells expressing Swedish mutant APP isoform 695 (APP695 Swe) when used at a concentration of 10 µM. Gypenoside XVII (40 mg/kg) prevents the formation of hippocampal and cortical Abeta plaques and ameliorates spatial cognitive deficits in the transgenic APP/PS1 mouse model of Alzheimer's disease. It decreases lipid deposition in the aortic sinus and serum levels of malondialdehyde (MDA), reduces aortic plaque area, and increases serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase in ApoE-/- mice. Gypenoside XVII (10 and 50 mg/kg) reduces spinal cord edema and neuronal apoptosis in a mouse model of mechanical compression-induced spinal cord injury. It also maintains retinal permeability and structure and reduces retinal levels of apoptotic proteins in a db/db mouse model of early diabetic retinopathy.Formal Name: 3beta-(beta-D-glucopyranosyloxy)-12beta-hydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. CAS Number: 80321-69-3. Synonyms: Gyp-17, Gyp-XVII, Gynosaponin S. Molecular Formula: C48H82O18. Formula Weight: 947.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.20 mg/ml, DMSO: 5 mg/ml. SMILES: C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)([H])CC2)C)O)([H])[C@]([C@](O[C@@H]6O[C@H](CO[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@H]6O)(C)CC/C=C(C)/C)([H])CC3)C. InChi Code: InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8,66-43-40(60)37(57)34(54)27(64-43)21-61-41-38(58)35(55)32(52)25(19-49)62-41)23-11-16-47(7)31(23)24(51)18-29-45(5)15-13-30(44(3,4)28(45)12-17-46(29,47)6)65-42-39(59)36(56)33(53)26(20-50)63-42/h10,23-43,49-60H,9,11-21H2,1-8H3/t23-,24+,25+,26+,27+,28-,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39+,40+,41+,42-,43-,45-,46+,47+,48-/m0/s1. InChi Key: ZRBFCAALKKNCJG-SJYBZOGZSA-N. Origin: Plant/Gynostemma pentaphyllum.
Keywords: Gynosaponin S, Gyp-17, Gyp-XVII, 3beta-(beta-D-glucopyranosyloxy)-12beta-hydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
Supplier: Cayman Chemical
Supplier-Nr: 34514

Properties

Application: Bioactive saponin
MW: 947.2 D
Formula: C48H82O18
Purity: >98%
Format: Solid

Database Information

CAS : 80321-69-3| Matching products
KEGG ID : K04520 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Gypenoside XVII"
Write a review
or to review a product.
Viewed