GW-806742X

GW-806742X
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SYN-1215-M001 1 mg -

3 - 9 business days*

119.00€
SYN-1215-M005 5 mg -

3 - 9 business days*

250.00€
SYN-1215-M010 10 mg -

3 - 9 business days*

421.00€
SYN-1215-M050 50 mg -

3 - 9 business days*

1,119.00€
SYN-1215-M100 100 mg -

3 - 9 business days*

-
 
Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase... more
Product information "GW-806742X"
Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL translocation to the membrane. Appears therefore to be a valuable reagent to inhibit necroptosis. It also provides an important proof-of-principle that targeting catalytically-dead pseudoenzymes represents a feasible, emerging therapeutic avenue.
Keywords: GW806742X, AC1NS7PT, AGN-PC-0LQ49Y
Supplier: SYNkinase
Supplier-Nr: 1215

Properties

Application: VEGFR2 inhibitor
MW: 573,6 D
Formula: C25H22F3N7O4S
Purity: >95%
Format: Solid

Database Information

CAS : 579515-63-2| Find alternatives
KEGG ID : K05098 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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