GSK1016790A

GSK1016790A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17289-1 1 mg -

6 - 10 business days*

43.00€
Cay17289-5 5 mg -

6 - 10 business days*

115.00€
Cay17289-10 10 mg -

6 - 10 business days*

187.00€
Cay17289-25 25 mg -

6 - 10 business days*

358.00€
 
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be... more
Product information "GSK1016790A"
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively). It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone.Formal Name: N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-benzo[b]thiophene-2-carboxamide. CAS Number: 942206-85-1. Molecular Formula: C28H32Cl2N4O6S2. Formula Weight: 655.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 223, 231, 286 nm. SMILES: ClC1=CC=C(S(N[C@H](C(N2CCN(C([C@@H](NC(C3=CC4=C(C=CC=C4)S3)=O)CC(C)C)=O)CC2)=O)CO)(=O)=O)C(Cl)=C1. InChi Code: InChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1. InChi Key: IVYQPSHHYIAUFO-VXKWHMMOSA-N.
Keywords: N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-benzo[b]thiophene-2-carboxamide
Supplier: Cayman Chemical
Supplier-Nr: 17289

Properties

Application: TRPV4 agonist
MW: 655.6 D
Formula: C28H32Cl2N4O6S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 942206-85-1| Matching products
KEGG ID : K04973 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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