GLX-351322

GLX-351322 is an inhibitor of NADPH oxidase 4 (NOX4, IC50 = 5 µM). It is selective for NOX4 over NOX2 (IC50 = 40 µM). GLX-351322 (10 µM) reduces glucose-induced production of reactive oxygen species (ROS) and cytotoxicity in isolated human pancreatic islets. It decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet when administered in the drinking water at an estimated dose of 3.8 mg/kg per day.Formal Name: 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid, ethyl ester. CAS Number: 835598-94-2. Molecular Formula: C21H25N3O5S. Formula Weight: 431.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: slightly soluble. lambdamax: 229, 253, 324 nm. SMILES: O=C(C1=C(NC(CN2CCN(CC2)C(C3=CC=CO3)=O)=O)SC4=C1CCC4)OCC. InChi Code: InChI=1S/C21H25N3O5S/c1-2-28-21(27)18-14-5-3-7-16(14)30-19(18)22-17(25)13-23-8-10-24(11-9-23)20(26)15-6-4-12-29-15/h4,6,12H,2-3,5,7-11,13H2,1H3,(H,22,25). InChi Key: KEVHLTCEMHIJTQ-UHFFFAOYSA-N.