Furosemide

Furosemide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17273-1 1 g -

6 - 10 business days*

43.00€
Cay17273-5 5 g -

6 - 10 business days*

76.00€
 
Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1... more
Product information "Furosemide"
Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both). In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs. Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy. It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (Kis = 0.052-0.065 µM) and organic ion transporter 1 (OAT1, Ki = 9.5 µM), as well as a GABAA receptor antagonist. This product is also available as an analytical reference standard (Cay-26298).Formal Name: 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoic acid. CAS Number: 54-31-9. Synonyms: Frusemide. Molecular Formula: C12H11ClN2O5S. Formula Weight: 330.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 234, 273, 343 nm. SMILES: ClC1=C(S(N)(=O)=O)C=C(C(O)=O)C(NCC2=CC=CO2)=C1. InChi Code: InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19). InChi Key: ZZUFCTLCJUWOSV-UHFFFAOYSA-N.
Keywords: Frusemide, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoic acid
Supplier: Cayman Chemical
Supplier-Nr: 17273

Properties

Application: NKCC inhibitor
MW: 330.7 D
Formula: C12H11ClN2O5S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 54-31-9| Matching products
KEGG ID : K10951 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H360
P Phrases: P201, P202, P264, P270, P280, P301+310, P308+313, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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