F-Amidine (trifluoroacetate salt)

F-Amidine (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10610-100 100 µg -

1 - 10 business days

32.00€
Cay10610-250 250 µg -

1 - 10 business days

74.00€
Cay10610-500 500 µg -

1 - 10 business days

142.00€
Cay10610-1 1 mg -

1 - 10 business days

250.00€
 
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and... more
Product information "F-Amidine (trifluoroacetate salt)"
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1 by covalently modifying an active site cysteine that is important for its catalytic activity. F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 µM, respectively).
Keywords: N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-benzamide, 2,2,2-trifluoroacetate
Supplier: Cayman Chemical
Supplier-Nr: 10610-1

Properties

Application: Peptidyl arginine deiminase (PAD) inhibitor
MW: 408.4 D
Formula: C14H19FN4O2 . CF3COOH
Purity: >95%
Format: Solution

Database Information

CAS : 877617-46-4| Search using CAS
KEGG ID : K01481 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H301, H311, H331, H370
P Phrases: P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P321, P303+P361+P353, P308+P311, P370+P378, P405, P403+P235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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