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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay28537-2 | 2 mg | - |
6 - 10 business days* |
611.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ethacrynic acid-d5 is intended for use as an internal standard for the quantification of... more
Product information "Ethacrynic Acid-d5"
Ethacrynic acid-d5 is intended for use as an internal standard for the quantification of ethacrynic acid (Cay-19536) by GC- or LC-MS. Ethacrynic acid is a loop diuretic with anticancer activity. It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM. Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 µM, respectively), and inhibits Wnt/beta-catenin signaling in a cell-based reporter assay. It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 µM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 µM, respectively). Ethacrynic acid (250 µg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Cay-11492, Cay-21567 ) or neratinib (Cay-18404) in a 4T1 murine breast cancer model. Formulations containing ethacrynic acid have been used in the treatment of edema.Formal Name: 2-(2,3-dichloro-4-(2-methylenebutanoyl-3,3,4,4,4-d5)phenoxy)acetic acid. CAS Number: 1330052-59-9. Molecular Formula: C13H7Cl2D5O4. Formula Weight: 308.2. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C(C(C([2H])([2H])C([2H])([2H])[2H])=C)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1. InChi Code: InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)/i1D3,3D2. InChi Key: AVOLMBLBETYQHX-WNWXXORZSA-N.
Keywords: | 2-(2,3-dichloro-4-(2-methylenebutanoyl-3,3,4,4,4-d5)phenoxy)acetic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28537 |
Properties
Application: | GC-MS, LC-MS, Internal standard, Quantification, aldehyde dehydrogenase inhibitor |
MW: | 308.2 D |
Formula: | C13H7Cl2D5O4 |
Purity: | >99% deuterated forms (d1-d5) |
Format: | Solid |
Database Information
CAS : | 1330052-59-9| Matching products |
KEGG ID : | K00128 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H312, H315, H319, H332, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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