Erastin

Erastin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17754-1 1 mg -

approx. 1-3 business days

44.00€
Cay17754-5 5 mg -

6 - 10 business days*

132.00€
Cay17754-10 10 mg -

6 - 10 business days*

219.00€
Cay17754-50 50 mg -

6 - 10 business days*

875.00€
 
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis... more
Product information "Erastin"
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide (Cay-14126), and beta-mercaptoethanol. Erastin (5 µM) inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells and inhibits glutamate release in an enzyme-coupled fluorescence assay (EC50 = 1.2 µM). It also selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml). Formal Name: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone. CAS Number: 571203-78-6. Molecular Formula: C30H31ClN4O4. Formula Weight: 547.1. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml. lambdamax: 225, 276, 304 nm. SMILES: O=C1C2=CC=CC=C2N=C(N1C3=CC=CC=C3OCC)C(N4CCN(CC4)C(COC5=CC=C(C=C5)Cl)=O)C. InChi Code: InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3. InChi Key: BKQFRNYHFIQEKN-UHFFFAOYSA-N.
Keywords: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Supplier: Cayman Chemical
Supplier-Nr: 17754

Properties

Application: Antitumor agent
MW: 547.1 D
Formula: C30H31ClN4O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 571203-78-6| Find alternatives
KEGG ID : K02833 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H311, H331
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P311, P312, P321, P330, P361+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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