EA4

EA4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10111-5 5 mg -

6 - 10 business days*

92.00€
Cay10111-10 10 mg -

6 - 10 business days*

174.00€
Cay10111-50 50 mg -

6 - 10 business days*

730.00€
Cay10111-100 100 mg -

6 - 10 business days*

1,278.00€
 
rPLA2 is a calcium-dependent cytosolic phospholipase A2 (cPLA2) initially isolated and... more
Product information "EA4"
rPLA2 is a calcium-dependent cytosolic phospholipase A2 (cPLA2) initially isolated and characterized from bovine and human red blood cells (RBCs). It has a molecular mass of 42 kDa and biochemical properties similar to cPLA2 Type IV. EA4 is a quinone derivative that inhibits rPLA2 with a Ki of 130 µM. It inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. EA4 causes significant time- and concentration-dependent induction of cytochrome P450 1A1 (CYP1A1) mRNA and protein in murine hepatoma Hepa-1c1c7 cells. EA4 also modulates CYP1A1 and CYP1B1 expression in other cell lines such as MCF-7, Hep-G2, and HL-60. Formal Name: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. CAS Number: 389614-94-2. Molecular Formula: C19H17ClN2O2. Formula Weight: 340.8. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:2): .3 mg/ml, Ethanol: 1 mg/ml. lambdamax: 202, 242, 280, 600 nm. SMILES: CCN(CC)c1ccc(cc1)C1=C(Cl)C(=O)c2ncccc2C1=O. InChi Code: InChI=1S/C19H17ClN2O2/c1-3-22(4-2)13-9-7-12(8-10-13)15-16(20)19(24)17-14(18(15)23)6-5-11-21-17/h5-11H,3-4H2,1-2H3. InChi Key: XAZVKSMDPVMMPP-UHFFFAOYSA-N.
Keywords: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione
Supplier: Cayman Chemical
Supplier-Nr: 10111

Properties

Application: CPLA2 inhibitor
MW: 340.8 D
Formula: C19H17ClN2O2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 389614-94-2| Find alternatives
KEGG ID : K01047 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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