E-64

E-64
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10007963-5 5 mg -

6 - 10 business days*

73.00€
Cay10007963-10 10 mg -

6 - 10 business days*

131.00€
Cay10007963-25 25 mg -

6 - 10 business days*

294.00€
Cay10007963-50 50 mg -

6 - 10 business days*

549.00€
 
E-64 is a fungal metabolite originally isolated from Aspergillus japonicus that has diverse... more
Product information "E-64"
E-64 is a fungal metabolite originally isolated from Aspergillus japonicus that has diverse biological activities. It inhibits a variety of cysteine proteases, including cathepsins B, H, and L, as well as papain, ficin, and bromelain, but not the serine proteases plasmin, trypsin, and tissue kallikrein or the aspartic protease pepsin. E-64 (0.1-2 mg/ml) reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease. It is active against the FCR3 P. falciparum strain with an IC50 value of 836 nM. E-64 (5-25 µM) reduces bone resorption in embryonic mouse bone explants.Formal Name: (2S,3S)-3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid. CAS Number: 66701-25-5. Molecular Formula: C15H27N5O5. Formula Weight: 357.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, Water: 20 mg/ml. SMILES: NC(=N)NCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)O. InChi Code: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11?/m0/s1. InChi Key: LTLYEAJONXGNFG-QRHSGQBVSA-N.
Keywords: (2S,3S)-3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 10007963

Properties

Application: Cysteine protease inhibitor
MW: 357.4 D
Formula: C15H27N5O5
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 66701-25-5| Matching products
KEGG ID : K01371 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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COVID-19 Research
E64 E64
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