Diclofenac (sodium salt)

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) induced by A23187 (Cay-11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.Formal Name: 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, monosodium salt. CAS Number: 15307-79-6. Molecular Formula: C14H10Cl2NO2 . Na. Formula Weight: 318.1. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 40 mg/ml, Ethanol: 35 mg/ml, PBS (pH 7.2): 9 mg/ml. lambdamax: 285 nm. SMILES: ClC1=C(N([H])C2=C(CC([O-])=O)C=CC=C2)C(Cl)=CC=C1.[Na+]. InChi Code: InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19,/h1-7,17H,8H2,(H,18,19),/q,+1/p-1. InChi Key: KPHWPUGNDIVLNH-UHFFFAOYSA-M.