Cyclosporin A

Cyclosporin A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay12088-25 25 mg -

6 - 10 business days*

43.00€
Cay12088-100 100 mg -

6 - 10 business days*

92.00€
 
Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase... more
Product information "Cyclosporin A"
Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM). It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT. Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.CAS Number: 59865-13-3. Synonyms: NSC 290193. Molecular Formula: C62H111N11O12. Formula Weight: 1202.6. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 3 mg/ml, Ethanol: 14 mg/ml. SMILES: O[C@@H]([C@](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)CC)=O)([H])N(C([C@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)[C@H](C)C/C=C/C. InChi Code: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(3. InChi Key: PMATZTZNYRCHOR-CGLBZJNRSA-N.
Keywords: NSC 290193
Supplier: Cayman Chemical
Supplier-Nr: 12088

Properties

Application: Immunosuppressant, Calcineurin inhibitor
MW: 1202.6 D
Formula: C62H111N11O12
Purity: >99%
Format: Solid

Database Information

CAS : 59865-13-3| Matching products
KEGG ID : K06268 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H350, H360
P Phrases: P201, P202, P264, P270, P280, P330, P301+P310, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Cyclosporin A"
Write a review
or to review a product.
Viewed