Cyclic Pifithrin-alpha (hydrobromide)

Cyclic Pifithrin-alpha (hydrobromide)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14748-5 5 mg -

6 - 10 business days*

77.00€
Cay14748-10 10 mg -

6 - 10 business days*

143.00€
Cay14748-25 25 mg -

6 - 10 business days*

333.00€
Cay14748-50 50 mg -

6 - 10 business days*

551.00€
 
Pifithrin-alpha (PFT-alpha, Cay-13326) is a reversible inhibitor of p53-dependent transcription... more
Product information "Cyclic Pifithrin-alpha (hydrobromide)"
Pifithrin-alpha (PFT-alpha, Cay-13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-alpha, also known as PFT-beta, is a stable analog of PFT-alpha, formed by the condensation of pifithrin-alpha in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 µM, respectively). At doses lower than those that inhibit growth, cyclic PFT-alpha induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 µM cyclic PFT-alpha blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.Formal Name: 5,6,7,8-tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole, monohydrobromide. CAS Number: 511296-88-1. Synonyms: Cyclic PFT-alpha, PFT-beta, Pifithrin-beta. Molecular Formula: C16H16N2S . HBr. Formula Weight: 349.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 260 nm. SMILES: CC(C=C1)=CC=C1C2=CN(C(S3)=N2)C4=C3CCCC4.Br. InChi Code: InChI=1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13,/h6-10H,2-5H2,1H3,1H. InChi Key: SGNCOAOESGSEOP-UHFFFAOYSA-N.
Keywords: Cyclic PFT-alpha, PFT-beta, Pifithrin-beta, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole, monohydrobromide
Supplier: Cayman Chemical
Supplier-Nr: 14748

Properties

Application: PFT-alpha analog, P53-dependent transcription / apoptosis inhibitor
MW: 349.3 D
Formula: C16H16N2S . HBr
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 511296-88-1| Matching products
KEGG ID : K04451 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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