CVT-10216

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the major oxidative pathway of alcohol metabolism. CVT-10216 is a reversible inhibitor of ALDH2 (IC50 = 29 nM) that demonstrates >40-fold selectivity for ALDH2 over the cytosolic isoform, ALDH1. CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats. This compound has also been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety. The efficacy of CVT-10216 has also been examined in rodent models of drug addiction or binge eating of high-fat or high-sugar diets.Formal Name: 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]-benzoic acid. CAS Number: 1005334-57-5. Synonyms: GS-455534. Molecular Formula: C24H19NO7S. Formula Weight: 465.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml. lambdamax: 234, 259 nm. SMILES: OC(C1=CC=CC(COC2=CC=C(C(C(C3=CC=C(NS(C)(=O)=O)C=C3)=CO4)=O)C4=C2)=C1)=O. InChi Code: InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28). InChi Key: YYOOFJZTRCPVFD-UHFFFAOYSA-N.