Compound E

Compound E
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15579-500 500 µg -

1 - 10 business days

194.00€
Cay15579-1 1 mg -

1 - 10 business days

330.00€
 
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by... more
Product information "Compound E"
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid precursor protein (APP), which is important in Alzheimer's disease. Compound E is a potent, cell-permeable, and selective inhibitor of gamma-secretase, blocking the cleavage of both APP and Notch CTFs with IC50 values of ~0.3 nM. Compound E induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by gamma-secretase.
Keywords: gamma-Secretase Inhibitor XXI, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
Supplier: Cayman Chemical
Supplier-Nr: 15579-1

Properties

Application: Gamma-Secretase inhibitor
MW: 490.5 D
Formula: C27H24F2N4O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 209986-17-4| Search using CAS
KEGG ID : K02599 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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