Cobimetinib, Free Base

Cobimetinib, Free Base
Item number Size Datasheet Manual SDS Delivery time Quantity Price
LC-C-1100_1mg 1 mg -

3 - 15 business days*

87.00€
LC-C-1100_5mg 5 mg -

3 - 15 business days*

103.00€
LC-C-1100_10mg 10 mg -

3 - 15 business days*

123.00€
LC-C-1100_25mg 25 mg -

3 - 15 business days*

194.00€
LC-C-1100_50mg 50 mg -

3 - 15 business days*

247.00€
LC-C-1100_100mg 100 mg -

3 - 15 business days*

401.00€
LC-C-1100_200mg 200 mg -

3 - 15 business days*

686.00€
 
Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to... more
Product information "Cobimetinib, Free Base"
Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses, cobimetinib inhibited pERK in tumors with an increased IC50 value of 3.9 µM in WM-266-4 xenograft mice. Wong H., et al. 'Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor.' Clin. Cancer Res. 18: 3090-3099 (2012). 18?F-FDG-PET imaging reflected cobimetinib and vemurafenib action across a wide range of metastatic melanomas.. Baudy A.R., et al. 'FDG-PET is a good biomarker of both early response and acquired resistance in BRAF V600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973.' EJNMMI Res. 2: 22 (2012). The combination treatment of cobimetinib with vemurafenib resulted in a significant improvement in progression-free survival among patients with BRAF V600-mutated metastatic melanoma. Larkin J. et al. 'Combined vemurafenib and cobimetinib in BRAF-mutated melanoma.' N. Engl. J. Med. 371: 1867-1876 (2014).
Keywords: GDC0973, RG7420, XL518
Supplier: LC Laboratories
Supplier-Nr: C-1100

Properties

Application: Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
MW: 531.31 D
Formula: C21H21F3IN3O2
Purity: >99%
Format: Solid

Database Information

CAS : 934660-93-2| Matching products
KEGG ID : K04368 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302+312+332
P Phrases: P262
Caution
Our products are for laboratory research use only: Not for administration to humans!
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