CCT018159

CCT018159
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10012591-1 1 mg -

6 - 10 business days*

17.00€
Cay10012591-5 5 mg -

6 - 10 business days*

74.00€
Cay10012591-10 10 mg -

6 - 10 business days*

130.00€
Cay10012591-50 50 mg -

6 - 10 business days*

569.00€
 
The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the... more
Product information "CCT018159"
The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways. Its activity is driven by ATP and regulated by co-chaperones such as Hsp72. CCT018159 is a 3,4-diaryl pyrazoloresorcinol compound that inhibits the ATPase activity of Hsp90 with IC50 values of 3.2 and 6.6 µM for human Hsp90beta and yeast Hsp90, respectively. At concentrations up to 100 µM, CCT018159 does not inhibit human Hsp72 ATPase or topoisomerase II, yet at 50 µM CCT018159 inhibits 13 out of a panel of 20 commonly studied kinases. In human tumor xenografts, such as SKMEL 28 melanoma cells, CCT018159 induces Hsp72 expression and dc-Raf, ERBB2, and Cdk4. Formal Name: 4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol. CAS Number: 171009-07-7. Molecular Formula: C20H20N2O4. Formula Weight: 352.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 268, 293 nm. SMILES: CCc1cc(c(O)cc1O)c1n[nH]c(C)c1c1ccc2OCCOc2c1. InChi Code: InChI=1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22). InChi Key: OWPMENVYXDJDOW-UHFFFAOYSA-N.
Keywords: 4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Supplier: Cayman Chemical
Supplier-Nr: 10012591

Properties

Application: Hsp90 inhibitor
MW: 352.4 D
Formula: C20H20N2O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 171009-07-7| Find alternatives
KEGG ID : K04079 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319
P Phrases: P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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