CAY10774

CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 15 nM in a homologous time-resolved fret (HTRF) assay). It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50 = 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs.Formal Name: (2S)-1-[[3-bromo-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid. CAS Number: 2714327-65-6. Molecular Formula: C26H25Br2NO3. Formula Weight: 559.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. SMILES: BrC1=C(COC2=CC=C(CN3CCCC[C@H]3C(O)=O)C=C2Br)C=CC=C1C4=CC=CC=C4. InChi Code: InChI=1S/C26H25Br2NO3/c27-22-15-18(16-29-14-5-4-11-23(29)26(30)31)12-13-24(22)32-17-20-9-6-10-21(25(20)28)19-7-2-1-3-8-19/h1-3,6-10,12-13,15,23H,4-5,11,14,16-17H2,(H,30,31)/t23-/m0/s1. InChi Key: AHFXYBDSOWECNI-QHCPKHFHSA-N.