CAY10774

CAY10774
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay32569-500 500 µg -

6 - 10 business days*

32.00€
Cay32569-1 1 mg -

6 - 10 business days*

60.00€
Cay32569-5 5 mg -

6 - 10 business days*

250.00€
Cay32569-10 10 mg -

6 - 10 business days*

438.00€
 
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1... more
Product information "CAY10774"
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 15 nM in a homologous time-resolved fret (HTRF) assay). It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50 = 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs. Formal Name: (S)-1-(3-bromo-4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid. Molecular Formula: C26H25Br2NO3. Formula Weight: 559.3. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. SMILES: BrC1=C(COC2=CC=C(CN3CCCC[C@H]3C(O)=O)C=C2Br)C=CC=C1C4=CC=CC=C4. InChi Code: InChI=1S/C26H25Br2NO3/c27-22-15-18(16-29-14-5-4-11-23(29)26(30)31)12-13-24(22)32-17-20-9-6-10-21(25(20)28)19-7-2-1-3-8-19/h1-3,6-10,12-13,15,23H,4-5,11,14,16-17H2,(H,30,31)/t23-/m0/s1. InChi Key: AHFXYBDSOWECNI-QHCPKHFHSA-N.
Keywords: (S)-1-(3-bromo-4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 32569

Properties

Application: PD-1/PD-L1 interaction inhibitor
MW: 559.3 D
Formula: C26H25Br2NO3
Purity: >95%
Format: Crystalline Solid

Database Information

KEGG ID : K06744 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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