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Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an IC50 value of 0.3 µM. This compound is ATP competitive, displaying a Ki value of 0.2 µM and only minimally inhibits the activities of other protein kinases (e.g., GSK3, Cdk5, and MSK1). Formal Name: 4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid. CAS Number: 19231-60-8. Molecular Formula: C10H3I4NO4. Formula Weight: 708.8. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) 1:5: 0.15 mg/ml, DMSO: 5 mg/ml. lambdamax: 263 nm. SMILES: OC(=O)CN1C(=O)c2c(C1=O)c(I)c(I)c(I)c2I. InChi Code: InChI=1S/C10H3I4NO4/c11-5-3-4(6(12)8(14)7(5)13)10(19)15(9(3)18)1-2(16)17/h1H2,(H,16,17). InChi Key: FLSXICNYHDJIAW-UHFFFAOYSA-N.