CAY10576

CAY10576
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011249-1 1 mg -

6 - 10 business days*

45.00€
Cay10011249-5 5 mg -

6 - 10 business days*

203.00€
Cay10011249-10 10 mg -

6 - 10 business days*

360.00€
Cay10011249-50 50 mg -

6 - 10 business days*

1,575.00€
 
The NF-kappaB/Rel transcription factors, known to be involved in the regulation of... more
Product information "CAY10576"
The NF-kappaB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IkappaB proteins. NF-kappaB is activated upon degradation of IkappaB following IKKalpha and IKKbeta phosphorylation. IKKepsilon, a homolog of IKKalpha and IKKbeta, can also activate NF-kappaB. IKKepsilon is expressed predominantly in immune cells, and is thought to play a role in the immune response. CAY10576 is a benzimidazole analog that selectively inhibits IKKepsilon with an IC50 value of 40 nM and is essentially inactive at IKKalpha and IKKbeta. Formal Name: 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile. CAS Number: 862812-98-4. Molecular Formula: C22H19N3O5S2. Formula Weight: 469.5. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (7.2 pH) (1:3): 0.25 mg/ml. lambdamax: 276, 294 nm. SMILES: CS(C1=C(COC2=C(C#N)SC(N3C=NC4=CC(OC)=C(OC)C=C43)=C2)C=CC=C1)(=O)=O. InChi Code: InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3. InChi Key: LDTAHRLHGHFHKP-UHFFFAOYSA-N.
Keywords: 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
Supplier: Cayman Chemical
Supplier-Nr: 10011249

Properties

Application: IKKepsilon inhibitor
MW: 469.5 D
Formula: C22H19N3O5S2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 862812-98-4| Find alternatives
KEGG ID : K07211 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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