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The NF-kappaB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IkappaB proteins. NF-kappaB is activated upon degradation of IkappaB following IKK-alpha and IKK-beta phosphorylation. IKK-epsilon, a homolog of IKK-alpha and IKK-beta, can also activate NF-kappaB. IKK-epsilon is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-epsilon with an IC50 value of ~15.8 µM. Formal Name: 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide. CAS Number: 916985-21-2. Molecular Formula: C22H21N3O6S2. Formula Weight: 487.6. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 1mg/mL, DMSO: 10mg/mL, DMSO:PBS(7.2pH) 1:4: 0.2mg/mL. lambdamax: 295 nm. SMILES: COc1cc2c(ncn2c2cc(OCc3ccc(cc3)S(=O)(=O)C)c(s2)C(=O)N)cc1OC. InChi Code: InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26). InChi Key: YYZTVTZCYVZGRB-UHFFFAOYSA-N.