BRD4770

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 µM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and -independent proliferation of PANC-1 cells.Formal Name: 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid, methyl ester. CAS Number: 1374601-40-7. Synonyms: HMTase Inhibitor VI. Molecular Formula: C25H23N3O3. Formula Weight: 413.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 232, 271, 329 nm. SMILES: O=C(C1=CC=CC=C1)NC2=NC3=CC(C(OC)=O)=CC=C3N2CCCC4=CC=CC=C4. InChi Code: InChI=1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29). InChi Key: UCGWYCMPZXDHNR-UHFFFAOYSA-N.