BMN 673

BMN 673
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay19782-1 1 mg -

6 - 10 business days*

97.00€
Cay19782-5 5 mg -

6 - 10 business days*

403.00€
Cay19782-10 10 mg -

6 - 10 business days*

710.00€
Cay19782-25 25 mg -

6 - 10 business days*

1,296.00€
 
BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of... more
Product information "BMN 673"
BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors in mice.Formal Name: (8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one. CAS Number: 1207456-01-6. Synonyms: Talazoparib. Molecular Formula: C19H14F2N6O. Formula Weight: 380.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 255, 309 nm. SMILES: O=C1NN=C2[C@H](C3=NC=NN3C)[C@@H](C4=CC=C(F)C=C4)NC5=C2C1=CC(F)=C5. InChi Code: InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1. InChi Key: HWGQMRYQVZSGDQ-HZPDHXFCSA-N.
Keywords: Talazoparib, (8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one
Supplier: Cayman Chemical
Supplier-Nr: 19782

Properties

Application: Antineoplastic, PARP inhibitor
MW: 380.4 D
Formula: C19H14F2N6O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1207456-01-6| Matching products
KEGG ID : K10798 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H341, H360, H372
P Phrases: P201, P202, P260, P264, P270, P280, P308+313, P314, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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