AZ9482

AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively). It induces centrosome declustering (EC50 = 50 = 3 nM).Formal Name: 2-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinecarbonitrile. CAS Number: 1825345-33-2. Molecular Formula: C26H22N6O2. Formula Weight: 450.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25mg/mL, DMSO: 0.15mg/mL. lambdamax: 265 nm. SMILES: O=C1C2=CC=CC=C2C(CC3=CC(C(N4CCN(C5=NC=CC=C5C#N)CC4)=O)=CC=C3)=NN1. InChi Code: InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33). InChi Key: ZDDPBFWHZOJFHF-UHFFFAOYSA-N.