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COVID-19 Research
Auranofin is a gold-thiol complex with diverse biological activities. It inhibits thioredoxin... more
Product information "Auranofin"
Auranofin is a gold-thiol complex with diverse biological activities. It inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial peroxiredoxin 3 (PRDX3), and induces apoptosis in Jurkat T cells. Auranofin reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes. It is active against P. falciparum and S. mansoni in vitro when used at concentrations ranging from 1 to 10 µM. In vivo, auranofin (2 mg/kg per day) reduces the number of peripheral blood mononuclear cells (PBMCs) containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of simian immunodeficiency virus (SIV). Auranofin (0.5 µM) synergizes with buthionine sulfoxime (BSO) to decrease glutathione peroxidase 4 (GPX4) levels, increase intracellular accumulation of reactive oxygen species (ROS), and induce ferroptosis in Huh7 and HepG2 hepatocellular carcinoma cells.Formal Name: [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold. CAS Number: 34031-32-8. Synonyms: NSC 321521, Ridauragold thiol, SKF 39162. Molecular Formula: C20H34AuO9PS. Formula Weight: 678.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Ethanol: 4 mg/ml. SMILES: CC(O[C@@H]([C@@H]([C@@H](COC(C)=O)O1)OC(C)=O)[C@H]([C@@H]1[S-][Au+][P](CC)(CC)CC)OC(C)=O)=O. InChi Code: InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18,1-4-7(5-2)6-3,/h10-14,24H,5H2,1-4H3,4-6H2,1-3H3,/q,,+1/p-1/t10-,11-,12+,13-,14+,,/m1../s1. InChi Key: AUJRCFUBUPVWSZ-XTZHGVARSA-M.
Keywords: | NSC 321521, Ridauragold thiol, SKF 39162, [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15316 |
Properties
Application: | Thioredoxin reductase inhibitor |
MW: | 678.5 D |
Formula: | C20H34AuO9PS |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 34031-32-8| Matching products |
KEGG ID : | K00384 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H301, H361 |
P Phrases: | P201, P202, P264, P270, P280, P301+310, P308+313, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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COVID-19 Research
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