AS-604850

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kgamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kalpha, beta, and delta are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kgamma with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant gamma, delta, beta, and alpha isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.Formal Name: 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione. CAS Number: 648449-76-7. Molecular Formula: C11H5F2NO4S. Formula Weight: 285.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): .5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 231, 328 nm. SMILES: O=C1NC(=O)/C(=C\c2ccc3OC(F)(F)Oc3c2)\S1. InChi Code: InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-. InChi Key: SRLVNYDXMUGOFI-YWEYNIOJSA-N.