AS-604850

AS-604850
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010175-1 1 mg -

6 - 10 business days*

25.00€
Cay10010175-5 5 mg -

6 - 10 business days*

113.00€
Cay10010175-10 10 mg -

6 - 10 business days*

200.00€
Cay10010175-25 25 mg -

6 - 10 business days*

438.00€
 
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of... more
Product information "AS-604850"
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kgamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kalpha, beta, and delta are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kgamma with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant gamma, delta, beta, and alpha isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg. Formal Name: 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione. CAS Number: 648449-76-7. Molecular Formula: C11H5F2NO4S. Formula Weight: 285.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): .5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 231, 328 nm. SMILES: O=C1NC(=O)/C(=C\c2ccc3OC(F)(F)Oc3c2)\S1. InChi Code: InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-. InChi Key: SRLVNYDXMUGOFI-YWEYNIOJSA-N.
Keywords: 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione
Supplier: Cayman Chemical
Supplier-Nr: 10010175

Properties

Application: PI3Kgamma inhibitor
MW: 285.2 D
Formula: C11H5F2NO4S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 648449-76-7| Find alternatives
KEGG ID : K00922 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H317
P Phrases: P261, P272, P280, P302+352, P321, P333+313, P362+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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