AG-99

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-99 is an inhibitor of EGF receptor kinase with an IC50 value of 10 µM in the human epidermoid carcinoma cell line A431.Formal Name: 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenamide. CAS Number: 122520-85-8. Synonyms: Tyrphostin 46, Tyrphostin AG-99. Molecular Formula: C10H8N2O3. Formula Weight: 204.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 254, 364 nm. SMILES: N#C/C(=C\c1ccc(O)c(O)c1)/C(=O)N. InChi Code: InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+. InChi Key: USOXQZNJFMKTKJ-XVNBXDOJSA-N.