ADP-TAMRA conjugate [5-TAMRA-eda-ADP]

ADP-TAMRA conjugate [5-TAMRA-eda-ADP]
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-13606 100 nmol -

3 - 8 business days*

Fluorescently labeled ADP molecules are used to screening ADP-binding enzymes and other protein... more
Product information "ADP-TAMRA conjugate [5-TAMRA-eda-ADP]"
Fluorescently labeled ADP molecules are used to screening ADP-binding enzymes and other protein targets for drug discovery. This ADP-TAMRA has been tested for binding kynurenine monooxygenase (KMO) with a K(d) value of 0.60 ± 0.05 ?M and to the NMOs from Aspergillus fumigatus and Mycobacterium smegmatis with K(d) values of 2.1 ± 0.2 and 4.0 ± 0.2 µM, respectively (Anal Biochem. 2012, 425, 80-7). The assay was tested in competitive binding experiments with substrates and products of KMO and an NMO. NMOs are essential for pathogenesis in fungi and bacteria. NMOs catalyze the hydroxylation of sine and ornithine in the biosynthesis of hydroxamate-containing siderophores. Inhibition of KMO, which catalyzes the conversion of kynurenine to 3-hydroxykynurenine, alleviates neurodegenerative disorders such as Huntington's and Alzheimer's diseases and brain infections caused by the parasite Trypanosoma brucei.
Supplier: AAT Bioquest
Supplier-Nr: 13606


Application: ADP-binding protein screening, Drug discovery
MW: 925,73 D
Format: Desiccated

Database Information

Handling & Safety

Storage: -20°C (protect from light)
Shipping: -20°C (International: -20°C)
Signal Word: Warning
P Phrases: P304, P312
Our products are for laboratory research use only: Not for administration to humans!
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