ACPT-I

ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 µM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 µM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 (Cay-14599) and flumazenil (Cay-14252), indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.Formal Name: (4beta)--amino-1alpha,2alpha,4-cyclopentanetricarboxylic acid. CAS Number: 194918-76-8. Molecular Formula: C8H11NO6. Formula Weight: 217.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 2mg/mL. SMILES: OC(=O)[C@H]1CC(N)(C[C@H]1C(=O)O)C(=O)O. InChi Code: InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15). InChi Key: FERIKTBTNCSGJS-UHFFFAOYSA-N.