Ac-DEVD-CHO

Ac-DEVD-CHO
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10017-500 500 µg -

6 - 10 business days*

45.00€
Cay10017-1 1 mg -

6 - 10 business days*

77.00€
Cay10017-5 5 mg -

6 - 10 business days*

288.00€
Cay10017-10 10 mg -

6 - 10 business days*

532.00€
 
Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23... more
Product information "Ac-DEVD-CHO"
Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively). Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively). Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Cay-14465), are irreversible. Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications. Formal Name: N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide, 2,2,2-trifluoroacetate. Synonyms: N-Ac-Asp-Glu-Val-Asp-CHO. Molecular Formula: C20H30N4O11 . XCF3COOH. Formula Weight: 502.5. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C([H])=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C20H30N4O11.C2HF3O2/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26,3-2(4,5)1(6)7/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32),(H,6,7)/t11-,12-,13-,17-,/m0./s1. InChi Key: PAIYHRXEVLCTGC-XVQUUFRESA-N.
Keywords: N-Ac-Asp-Glu-Val-Asp-CHO, N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide, 2,2,2-trifluoroacetate
Supplier: Cayman Chemical
Supplier-Nr: 10017

Properties

Application: Caspase-3 inhibitor
MW: 502.5 D
Formula: C20H30N4O11 . XCF3COOH
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 184179-08-6| Find alternatives
KEGG ID : K02187 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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