ABT-888 (hydrochloride)

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.Formal Name: 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride. CAS Number: 912445-05-7. Synonyms: Veliparib. Molecular Formula: C13H16N4O . 2HCl. Formula Weight: 317.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 15 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 269, 292 nm. SMILES: NC(C1=CC=CC2=C1N=C([C@@]3(NCCC3)C)N2)=O.Cl.Cl. InChi Code: InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12,,/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17),2*1H/t13-,,/m1../s1. InChi Key: DSBSVDCHFMEYBX-FFXKMJQXSA-N.