Item number Size Datasheet Manual SDS Delivery time Quantity Price
SYN-1001-M001 1 mg

3 - 9 business days*

SYN-1001-M005 5 mg -

3 - 9 business days*

SYN-1001-M010 10 mg -

3 - 9 business days*

SYN-1001-M050 50 mg -

3 - 9 business days*

SYN-1001-M100 100 mg -

3 - 9 business days*

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of... more
Product information "ABT-737"
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <1 nM) and also shows a very high specificity over Mcl-1 and A1. Target: Bcl-2
Keywords: ABT737
Supplier: SYNkinase
Supplier-Nr: 1001


Application: Bcl-2 / Bcl-X(L) / Bcl-w inhibitor
MW: 813,4 D
Formula: C42H45ClN6O5S2
Purity: >95%
Format: Solid

Database Information

CAS : 852808-04-9| Find alternatives
KEGG ID : K02161 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Our products are for laboratory research use only: Not for administration to humans!
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