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Resminostat
Item number: TGM-T6637-10mg
Description: Resminostat (4SC-201) is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Target: HDAC. Smiles: S(=O)(=O)(N1C=C(/C=C/C(NO)=O)C=C1)C2=CC=C(CN(C)C)C=C2. References: Mandl-Weber S, et al. Br J Haematol, 2010, 149(4), 518-528.
| Keywords: | 4SC-201, RAS2410 |
| CAS | 864814-88-0 |
| MW: | 349.4 D |
From 93.00€
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Retapamulin
Item number: TGM-T6638-100mg
Description: Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM). Target: Antibiotic, Antibacterial, ribosome. Smiles: CC1CCC23CCC(=O)C2C1(C)C(CC(C)(C=C)C(O)C3C)OC(=O)CSC1CC2CCC(C1)N2C. References: Champney WS, et al. Antimicrob...
| Keywords: | SB-275833 |
| Application: | Antibiotic, Protein biosynthesis inhibitor |
| CAS | 224452-66-8 |
| MW: | 517.76 D |
From 31.00€
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RG2833
Item number: TGM-T6639-100mg
Description: RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. Target: HDAC. Smiles: Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N. References: Rai M, et al. PLoS One. 2010, 5(1), e8825.
| Keywords: | RGFP109 |
| Application: | Brain-penetrant HDAC inhibitor |
| CAS | 1215493-56-3 |
| MW: | 339.43 D |
From 30.00€
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Rilmenidine Phosphate
Item number: TGM-T6641-100mg
Description: Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. Target: Imidazoline Receptor, Adrenergic Receptor, Autophagy, Apoptosis. Smiles: C1CC1C(C1CC1)NC1=NCCO1.OP(=O)(O)O. References: Rubinsztein DC, Bento CF, Deretic V.J Exp Med. 2015 Jun 29,212(7):979-90.
| CAS | 85409-38-7 |
| MW: | 278.24 D |
From 30.00€
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Rimantadine
Item number: TGM-T6642-100mg
Description: Rimantadine (1-Rimantadine) (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 µM. Target: Influenza Virus. Smiles: CC(N)C12CC3CC(CC(C3)C1)C2. References: Tzeng JI,et al.Neurosci Lett. 2016 Apr 8,618:94-8.
| Keywords: | 1-Rimantadine |
| Application: | Targets Influenza A virus matrix protein 2 (M2) |
| CAS | 13392-28-4 |
| MW: | 179.3 D |
From 30.00€
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Ro 31-8220 Mesylate
Item number: TGM-T6643-100mg
Description: Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-alpha/betaI/betaII/gamma/epsilon (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3beta. Target: PKC. Smiles:...
| Keywords: | Bisindolylmaleimide IX mesylate, Ro 31-8220 methanesulfonate, Bisindolylmaleimide IX |
| Application: | PKC inhibitor |
| CAS | 138489-18-6 |
| MW: | 553.65 D |
From 42.00€
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Ro 31-8220
Item number: TGM-T6643L-100mg
Description: Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3beta with IC50 values of 3, 8, 15, and 38 nM,...
| CAS | 125314-64-9 |
| MW: | 457.55 D |
From 1,440.00€
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Ropivacaine hydrochloride monohydrate
Item number: TGM-T6645-100mg
Description: Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. Target: Sodium Channel, Potassium Channel. Smiles: O.Cl.CCCN1CCCCC1C(=O)Nc1c(C)cccc1C. References: Simpson D, et al. Drugs, 2005,...
| Keywords: | LEA 103, LEA-103 HCl, Ropivacaine HCl monohydrate, Ropivacaine HCl |
| Application: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 132112-35-7 |
| MW: | 328.88 D |
From 31.00€
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Rotigotine-
Item number: TGM-T6647-100mg
Description: Rotigotine (N-0923) is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal patch, Rotigotine has not been associated with serum enzyme elevations during treatment or with episodes of clinically apparent liver...
| Keywords: | SPM 962, N-0437, N-0923, Neupro |
| Application: | Targets dopamine receptor D2 (DRD2) |
| CAS | 99755-59-6 |
| MW: | 315.47 D |
From 46.00€
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Rotundine
Item number: TGM-T6648-100mg
Description: Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. Target: 5-HT Receptor, Dopamine Receptor. Smiles: O(C)C=1C=C2[C@]3(N(CC=4C(C3)=CC=C(OC)C4OC)CCC2=CC1OC)[H]. References: Wang JB, et al. Future Med Chem, 2012, 4(2), 177-186.
| Keywords: | Gindarine, L-Tetrahydropalmatine, Caseanine, (-)-Tetrahydropalmatine |
| Application: | Dopamine D2 receptor antagonist |
| CAS | 483-14-7 |
| MW: | 355.43 D |
From 30.00€
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(S)-(+)-Rolipram
Item number: TGM-T6649-100mg
Description: (S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with an IC50 of 0.75 µM and exhibits anti-inflammatory and anti-depressant activity in the central nervous system, though it is less potent than its R enantiomer. Target: PDE, Apoptosis. Smiles:...
| Keywords: | S- (+)-Rolipram, (S)-Rolipram, (+)-Rolipram |
| CAS | 85416-73-5 |
| MW: | 275.34 D |
From 30.00€
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Sabutoclax
Item number: TGM-T6650-100mg
Description: Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 µM, 0.32 µM, 0.20 µM and 0.62 µM, respectively. Target: BCL. Smiles: CC(CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NC[C@H](C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1. References: Yunhui...
| Keywords: | BI-97C1 |
| Application: | Pan-Bcl-2 inhibitor |
| CAS | 1228108-65-3 |
| MW: | 700.78 D |
From 60.00€
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