6(5H)-Phenanthridinone

6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (EC50s = 10.2 and 36.3 µM, respectively, in yeast cells expressing the human enzymes). It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells when used at a concentration of 50 µM. 6(5H)-Phenanthridinone reduces NF-kappaB-induced transcription of the genes encoding TNF-alpha, IL-2, and IFN-gamma in rat lymphocytes. In vivo, 6(5H)-phenanthridinone (60 mg/kg) reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1beta, TNF-alpha, IL-2, and IFN-gamma and reduces disease score in a rat model of experimental autoimmune encephalomyelitis (EAE). It also decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity when administered at a dose of 10 mg/kg.CAS Number: 1015-89-0. Synonyms: NSC 11021, NSC 40943, NSC 61083. Molecular Formula: C13H9NO. Formula Weight: 195.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1mg/mL, DMF:PBS (pH 7.2) (1:5): 0.16mg/mL. lambdamax: 231, 237, 250, 259, 323, 337 nm. SMILES: O=C1C2=C(C=CC=C2)C3=CC=CC=C3N1. InChi Code: InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15). InChi Key: RZFVLEJOHSLEFR-UHFFFAOYSA-N.