5-Iodotubercidin

5-Iodotubercidin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010375-100 100 µg -

6 - 10 business days*

17.00€
Cay10010375-250 250 µg -

6 - 10 business days*

37.00€
Cay10010375-1 1 mg -

6 - 10 business days*

98.00€
Cay10010375-5 5 mg -

6 - 10 business days*

325.00€
 
5-Iodotubercidin (Itu) is an adenosine derivative that initiates glycogen synthesis in... more
Product information "5-Iodotubercidin"
5-Iodotubercidin (Itu) is an adenosine derivative that initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase alpha and activation of glycogen synthase alpha (maximal effects with ~20 µM Itu). Itu can inhibit a broad range of PKs including PKA (IC50 = 5-10 µM), phosphorylase kinase (IC50 = 5-10 µM), casein kinase I (IC50 = 0.4 µM) and II (IC50 = 10.9 µM), and PKC (IC50 = 0.4 µM), which appears to account for its glycogenic action. Itu is also a highly potent inhibitor of ERK2 (Ki = 525 nM), a protein kinase with important roles in cell proliferation. Mediated by the inhibition of acetyl-CoA carboxylase, Itu increases fatty acid oxidation activity of the liver at the expense of lipogenesis. Formal Name: 5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS Number: 24386-93-4. Synonyms: Itu, NSC 113939. Molecular Formula: C11H13IN4O4. Formula Weight: 392.2. Purity: >95%. Formulation: A solution in ethanol. Solubility: 0.1 M HCl: 0.7 mg/ml, 0.1 M NaOH: 0.8 mg/ml, DMF: 10 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 207, 284 nm. SMILES: IC1=CN([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C3=C1C(N)=NC=N3. InChi Code: InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1. InChi Key: WHSIXKUPQCKWBY-IOSLPCCCSA-N.
Keywords: Itu, NSC 113939, 5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Supplier: Cayman Chemical
Supplier-Nr: 10010375

Properties

Application: MAPK Inhibitor
MW: 392.2 D
Formula: C11H13IN4O4
Purity: >95%
Format: Solution

Database Information

CAS : 24386-93-4| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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