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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CDX-B0301-G001 | 1 g | - | - |
3 - 9 business days* |
68.00€
|
||
CDX-B0301-G005 | 5 g | - | - |
3 - 9 business days* |
260.00€
|
The synthetic nucleoside 5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA... more
Product information "5-Bromo-2'-deoxyuridine"
The synthetic nucleoside 5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA and commonly used in the detection of proliferating cells in living tissues. It can be incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies with fluorescent tags to target the BrdU incorporation for detection via flow cytometry or fluorescence microscopy. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. BrdU is also used as a mutagen in genetic research. BrdU stimulates cellular differentiation and maturation in leukemia cell lines, while it inhibits differentiation of friend erythroleukemia cells. BrdU replaces Oct-4 in transcription factor-mediated reprogramming of somatic cells and can be used in small molecule cocktail to generate ciPSCs. Product References: (1) N. Kee, et al., J. Neurosci. Methods 115, 97 (2002) , (2) R.C. Leif, et al., Cytometry A 58, 45 (2004) (Review) , (3) P. Taupin, Brain Res. Rev. 53, 198 (2007) (Review) , (4) D.W. Stacey & M. Hitomi, Cytometry A 73, 270 (2008) , (5) B.L. Cavanagh, et al., Molecules 16, 7980 (2011) , (6) B. Lehner, et al., Cell Tissue Res. 345, 313 (2011) , (7) T. Konishi, et al., J. Radiat. Res. 52, 433 (2011) , (8) J.M. Barker, et al., PLoS One 8, e63692 (2013) , (9) Y. Long, et al., Cell Res. 25, 1171 (2015) Appearance: White powder. Solubility: Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (25mg/ml) or water (10mg/ml). Identity: Determined by 1H-NMR. InChi Key: WOVKYSAHUYNSMH-RRKCRQDMSA-N Smiles: O[C@H]1C[C@H](N2C=C(Br)C(NC2=O)=O)O[C@@H]1CO
Keywords: | 5-BrdU, 5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR, Bromodeoxyuridine, Broxuridine, NSC 38297 |
Supplier: | Chemodex |
Supplier-Nr: | B0301 |
Properties
Application: | Thymidine analog, DNA labelling |
MW: | 307.1 D |
Formula: | C9H11BrN2O5 |
Purity: | >99% (HPLC) |
Format: | Solid |
Database Information
CAS : | 59-14-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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