Rapamycin

Rapamycin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13346-1 1 mg -

6 - 10 business days*

50.00€
Cay13346-5 5 mg -

6 - 10 business days*

115.00€
Cay13346-10 10 mg -

6 - 10 business days*

185.00€
Cay13346-25 25 mg -

6 - 10 business days*

432.00€
 
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1... more
Product information "Rapamycin"
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml. It also induces autophagy in a variety of cell types. Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM. Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.Formal Name: (7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone. CAS Number: 53123-88-9. Synonyms: AY 22989, NSC 226080, Sirolimus, Wy 090217. Molecular Formula: C51H79NO13. Formula Weight: 914.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 268, 278, 289 nm. SMILES: O=C([C@]1([H])CCCCN1C(C([C@@]2(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C3)C)([H])O2)=O)=O)O[C@](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@@H]3C)=O)=O)([H])[C@H](C)C[C@H]4C[C@@H](OC)[C@H](O)CC4. InChi Code: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,. InChi Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N. Origin: Bacterium/Streptomyces hygroscopicus.
Keywords: AY 22989, NSC 226080, Wy 090217, (7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epo
Supplier: Cayman Chemical
Supplier-Nr: 13346

Properties

Application: mTORC1 blocking
MW: 914.2 D
Formula: C51H79NO13
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 53123-88-9| Matching products
KEGG ID : K07203 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H351, H361, H372
P Phrases: P201, P202, P260, P264, P270, P280, P308+313, P314, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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