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Pipemidic acid is an antibiotic and derivative of piromidic acid (Cay-19255). It is active against clinical isolates of E. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, and V. parahaemolyticus (MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates of E. coli, P. mirabilis, Klebsiella, and Shigella (MICs = 1.56-6.25 µg/ml). Pipemidic acid is protective against systemic S. aureus, E. coli, K. pneumoniae, and P. aeruginosa infections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively). It is also protective against P. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well as E. coli, K. pneumoniae, and P. aeruginosa urinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice.Formal Name: 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido[2,3-d]pyrimidine-6-carboxylic acid, trihydrate. CAS Number: 72571-82-5. Molecular Formula: C14H17N5O3 . 3H2O. Formula Weight: 357.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.50 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 280 nm. SMILES: O=C(C1=CN(CC)C2=NC(N3CCNCC3)=NC=C2C1=O)O.O.O.O. InChi Code: InChI=1S/C14H17N5O3.3H2O/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19,,,/h7-8,15H,2-6H2,1H3,(H,21,22),3*1H2. InChi Key: URMXYPLWYMOYPG-UHFFFAOYSA-N.
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