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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay15386-500 | 500 µg | - |
6 - 10 business days* |
240.00€
|
|||
Cay15386-2.5 | 2500 µg | - |
6 - 10 business days* |
1,077.00€
|
Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates... more
Product information "Ikarugamycin"
Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity. It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases. It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 µM. Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.Formal Name: (2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. CAS Number: 36531-78-9. Molecular Formula: C29H38N2O4. Formula Weight: 478.6. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=C(C1=C(O)[C@H](CCCN2)NC1=O)/C=C/[C@@H]3C[C@@]4([H])[C@@](C=C[C@]5([H])[C@]4([H])C[C@@H](C)[C@H]5CC)([H])[C@H]3C/C=C\C2=O. InChi Code: InChI=1S/C29H38N2O4/c1-3-18-16(2)14-22-20(18)10-11-21-19-6-4-8-26(33)30-13-5-7-24-28(34)27(29(35)31-24)25(32)12-9-17(19)15-23(21)22/h4,8-12,16-24,34H,3,5-7,13-15H2,1-2H3,(H,30,33)(H,31,35)/b8-4-,12-9+/t16-,17-,18-,19+,20+,21-,22+,23+,24+/m1/s1. InChi Key: WSUGGLXIPUHOSG-QOMLVTEJSA-N. Origin: Bacterium/Streptomyces sp..
Keywords: | (2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15386 |
Properties
Application: | Antibiotic |
MW: | 478.6 D |
Formula: | C29H38N2O4 |
Purity: | >99% |
Format: | Solid |
Database Information
CAS : | 36531-78-9| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H301 |
P Phrases: | P264, P270, P321, P330, P301+P310, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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