HSGN-218

HSGN-218 is a gut-restrictive antibiotic. It is active against C. difficile (MIC = 0.007 µg/ml) and clinical isolates of C. difficile (MICs = 0.003-0.03 µg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 µg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice from C. difficile recurrence in mouse models of C. difficile infection.Formal Name: N-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]-4-[(trifluoromethyl)thio]-benzamide. CAS Number: 2519410-44-5. Molecular Formula: C16H8Cl2F3N3O2S. Formula Weight: 434.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 281 nm. SMILES: ClC1=CC(Cl)=CC(C2=NN=C(NC(C3=CC=C(SC(F)(F)F)C=C3)=O)O2)=C1. InChi Code: InChI=1S/C16H8Cl2F3N3O2S/c17-10-5-9(6-11(18)7-10)14-23-24-15(26-14)22-13(25)8-1-3-12(4-2-8)27-16(19,20)21/h1-7H,(H,22,24,25). InChi Key: YNSLXRYEPGHGRY-UHFFFAOYSA-N.