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Garenoxacin is a quinolone antibiotic. It is active against a variety of Gram-positive and... more
Product information "Garenoxacin"
Garenoxacin is a quinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria (MIC90s = 0.025-6.25 and 0.0125-100 µg/ml, respectively). Garenoxacin inhibits E. coli DNA gyrase supercoiling and S. aureus topoisomerase IV decatenation activities (IC50s = 0.17 and 2.19 mg/L, respectively). It is selective for S. aureus topoisomerase IV over human topoisomerase II (IC50 = 509.7 µg/L). Garenoxacin is efficacious against systemic quinolone-resistant S. aureus infection and pneumonia induced by the penicillin-resistant S. pneumoniae clinical isolate D-979 in mice (ED50s = 0.0189 and 0.0278 mg/animal, respectively).Formal Name: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. CAS Number: 194804-75-6. Synonyms: BMS-284756, T-3811ME. Molecular Formula: C23H20F2N2O4. Formula Weight: 426.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml. lambdamax: 221, 286 nm. SMILES: C[C@@H]1NCC2=CC(C3=CC=C(C(C(C(O)=O)=CN4C5CC5)=O)C4=C3OC(F)F)=CC=C12. InChi Code: InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m0/s1. InChi Key: NJDRXTDGYFKORP-NSHDSACASA-N.
Keywords: | BMS-284756, T-3811ME, 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33599 |
Properties
Application: | Quinolone antibiotic, Antibacterial, Nucleic acid biosynthesis inhibitor |
MW: | 426.4 D |
Formula: | C23H20F2N2O4 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 194804-75-6| Matching products |
KEGG ID : | K02621 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H301, H361 |
P Phrases: | P201, P202, P264, P270, P280, P301+310, P308+313, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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