Bafilomycin A1

Bafilomycin A1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11038-500 500 µg -

6 - 10 business days*

94.00€
Cay11038-1 1 mg -

approx. 1-3 business days

179.00€
Cay11038-5 5 mg -

6 - 10 business days*

798.00€
 
Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and an inhibitor of... more
Product information "Bafilomycin A1"
Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and an inhibitor of vacuolar H+-ATPases (V-ATPases, IC50s = 4, 50, and 400 nM for the Z. mays, bovine adrenal medulla, and N. crassa enzymes, respectively). It is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Formal Name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one. CAS Number: 88899-55-2. Synonyms: NSC 381866. Molecular Formula: C35H58O9. Formula Weight: 622.8. Purity: >95%. Formulation: A crystalline solid. Solubility: DMSO: 5 mg/ml, Methanol: 5 mg/ml. lambdamax: 248, 288 nm. SMILES: C[C@H]([C@@](C[C@H]1O)(O[C@H](C(C)C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C. InChi Code: InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-. InChi Key: XDHNQDDQEHDUTM-JQWOJBOSSA-N. Origin: Bacterium/Streptomyces sp..
Keywords: NSC 381866, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Supplier: Cayman Chemical
Supplier-Nr: 11038

Properties

Application: V-ATPase inhibitor
MW: 622.8 D
Formula: C35H58O9
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 88899-55-2| Find alternatives
KEGG ID : K02146 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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