Anhydrotetracycline (hydrochloride)

Anhydrotetracycline (hydrochloride)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009542-50 50 mg -

1 - 10 business days

45.00€
Cay10009542-100 100 mg -

1 - 10 business days

85.00€
Cay10009542-250 250 mg -

1 - 10 business days

158.00€
Cay10009542-500 500 mg -

1 - 10 business days

225.00€
 
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to... more
Product information "Anhydrotetracycline (hydrochloride)"

The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.

Keywords: 4-(dimethylamino)-1,4S,4aS,5,12,12aS-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10009542-50

Properties

Application: Antibiotic
MW: 462.9 D
Formula: C22H22N2O7 . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 13803-65-1| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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