Amoxicillin (hydrate)

Amoxicillin is an orally bioavailable, semisynthetic beta-lactam antibiotic. It inhibits the growth of 30 isolates of P. mirabilis and 89% of 30 E. coli strains when used at concentrations greater than or equal to 5 and 10 µg/ml, respectively, but resistance develops in strains of Klebsiella, Enterobacter, and indole-positive Proteus species. Amoxicillin is susceptible to bacterial beta-lactamases but is active against beta-lactamase-producing bacteria when used in combination with beta-lactamase antibiotics such as clavulanic acid with MIC values of greater than 4,096 and 16 µg/ml without or with clavulanic acid, respectively, against 46 clinical isolates of beta-lactamase-producing E. coli. Formulations containing amoxicillin have been used in the treatment of a variety of bacterial infections.Formal Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, trihydrate. CAS Number: 61336-70-7. Molecular Formula: C16H19N3O5S . 3H2O. Formula Weight: 419.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 25 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 232, 275 nm. SMILES: OC1=CC=C([C@@H](N)C(N[C@@H]2C(N3[C@]2([H])SC(C)(C)[C@@H]3C(O)=O)=O)=O)C=C1.O.O.O. InChi Code: InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7,,,/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24),3*1H2/t9-,10-,11+,14-,,,/m1.../s1. InChi Key: MQXQVCLAUDMCEF-CWLIKTDRSA-N.