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Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks... more
Product information "Actinomycin D"
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death. Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Cay-11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.Formal Name: 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide. CAS Number: 50-76-0. Synonyms: Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K. Molecular Formula: C62H86N12O16. Formula Weight: 1255.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 204, 240, 444 nm. SMILES: CC1=C2C(C(C(N[C@H](C(N[C@@H](C(C)C)C(N3[C@@](C(N(C)CC4=O)=O)([H])CCC3)=O)=O)[C@@H](C)OC([C@H](C(C)C)N4C)=O)=O)=C(N)C1=O)=NC5=C(C(N[C@@H]([C@@H](C)OC([C@H](C(C)C)N(C)C(CN(C([C@]6([H])CCCN6C([C@H](C(C)C)N7)=O)=O)C)=O)=O)C7=O)=O)C=CC(C)=C5O2. InChi Code: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(. InChi Key: RJURFGZVJUQBHK-DCUCITLNSA-N.
Keywords: | Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazi |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11421 |
Properties
Application: | Cancer studies, antineoplastic |
MW: | 1255.5 D |
Formula: | C62H86N12O16 |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 50-76-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H300, H350, H360 |
P Phrases: | P201, P202, P264, P270, P280, P321, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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