Chemicals

As the former name of Biomol GmbH (Biomol Fine Chemicals GmbH) already suggests: For more than 50 years we provide a wide range of inorganic and organic chemicals for research needs. Just search with a chemical name, or even better with a CAS number (Chemical Abstracts Service Registry Number). CAS numbers are unique identifiers and lead, in contrast to the different spelling options of a substance, to better results. According to our slogan: "You have the vision, we have the substance."

As the former name of Biomol GmbH (Biomol Fine Chemicals GmbH) already suggests: For more than 50 years we provide a wide range of inorganic and organic chemicals for research needs. Just search... read more »
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Chemicals

As the former name of Biomol GmbH (Biomol Fine Chemicals GmbH) already suggests: For more than 50 years we provide a wide range of inorganic and organic chemicals for research needs. Just search with a chemical name, or even better with a CAS number (Chemical Abstracts Service Registry Number). CAS numbers are unique identifiers and lead, in contrast to the different spelling options of a substance, to better results. According to our slogan: "You have the vision, we have the substance."

1447 from 1490 pages
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Tofacitinib
Tofacitinib

Item number: BPS-27037

Tofacitinib, also known as Tasocitinib, is a novel inhibitor of Janus kinase 3 (JAK3), a critical cytoplasmic tyrosine kinase in the signaling pathways of multiple cytokines. Research suggests Tofacitinib acts as an immunosuppressant, preventing organ transplant rejection, and that it has potential to alleviate symptoms of autoimmune diseases, such as rheumatoid arthritis...
Application: JAK3 inhibitor
MW: 312.4 D
308.00€
Review
LY-294002
LY-294002

Item number: BPS-27038

Specific inhibitor (IC50 = 1.40 µM) of phosphatidylinositol 3-kinase (PI3K).
Application: PI3K inhibitor
MW: 307.3 D
217.00€
Review
Roscovitine
Roscovitine

Item number: BPS-27040

Roscovitine is a potent inhibitor of p34cdc2 (IC50 = 0.2 µM). Also inhibits p33cdk2 and p33cdk5.
Application: P34cdc2 inhibitor
MW: 354.5 D
253.00€
Review
PJ34
PJ34

Item number: BPS-27041

A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP, EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350, EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.
Application: PARP inhibitor
MW: 331.8 D
199.00€
Review
Brefeldin A
Brefeldin A

Item number: BPS-27042

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus and induces apoptosis in human tumor cells via caspase activation. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.
Application: ER to Golgi protein transport inhibitor, GBF1 inhibitor
MW: 280.4 D
299.00€
Review
PAC-1
PAC-1

Item number: BPS-27043

Procaspase-activating compound, activates procaspase-3 to produce caspase-3 (EC50 = 0.22 µM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 µM). Pro-apoptotic, induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 µM respectively). PAC-1 had an IC50 value of 3 nM...
Application: Procaspase-?3 activator
MW: 392.5 D
290.00€
Review
Obatoclax
Obatoclax

Item number: BPS-27044

Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. Obatoclax inhibited primary acute myeloid leukemia (AML) progenitor cell proliferation with an average IC50 of 0.18 ± 0.07 µM, and it potently induced apoptosis in primary...
Application: BH3 mimetic
MW: 413.5 D
217.00€
Review
BIIB021
BIIB021

Item number: BPS-27046

BIIB021 is an orally available, synthetic small-molecule Hsp90 inhibitor. It binds in the ATP-binding pocket of Hsp90 (Ki = 1.7 ± 0.4 nM) and induces HER-2 degradation with an EC50 of 38 ± 10 nM in MCF-7 cells. It ncreases expression of the heat shock proteins Hsp90alpha and Hsp70, but has no effect on expression of the nonclient protein phosphatidylinositol 3-kinase p85...
Application: Hsp90 inhibitor
MW: 318.8 D
235.00€
Review
Okadaic Acid
Okadaic Acid

Item number: BPS-27047

Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2 classes, in numerous cell types. Non-phorbol type tumor promoter.
Application: Protein phosphatase inhibitor
MW: 805 D
299.00€
Review
AICAR
AICAR

Item number: BPS-27049

AICAR, also known as acadesine, is an adenosine regulating agent and AMPK activator. AICAR was found to activate AMP-activated protein kinase (AMPK) in skeletal muscle, inhibit acetyl-CoA carboxylase, reduce malonyl-CoA, and increase fatty acid oxidation and glucose uptake. Note: This product is not 5'-phosphorylated.
Application: AMPK activator
MW: 258.2 D
199.00€
Review
CTPB
CTPB

Item number: BPS-27050

CTPB is a potent activator of p300 activity, but not of PCAF (p300/CBP-associated factor). This compound has been shown to enhance p300 HAT-dependent transcriptional activation from in vitro assembled chromatin template. CTPB has also been noted to be a membrane-impermeable molecule that requires a carrier to move across the membrane barrier of cells.
Application: P300 inhibitor
MW: 554.1 D
208.00€
Review
Telaprevir (VX-950)
Telaprevir (VX-950)

Item number: BPS-27051

Telaprevir inhibits the hepatitis C virus NS3-4A serine protease, leading to the block of viral polyprotein processing. This eventually leads to a decrease of viral RNA replication, HCV RNA levels, as well as and protein levels in the Con1 (genotype 1b) subgenomic HCV replicon cells. This occurs in a time- and dose-dependent manner.
Application: Hepatitis C virus NS3/NS4A protease inhibitor
MW: 679.8 D
1,014.00€
Review
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