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Py-MAA-Val-Cit-PAB-DX8951
Item number: TGM-T75117-50mg
Description: Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1]. Target: Others
| CAS | 2504068-37-3 |
| MW: | 1164.26 D |
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KRASG12C IN-2
Item number: TGM-T75119-50mg
Description: KRASG12C IN-2 (compound 17) is an orally active KRAS G12C inhibitor that effectively suppresses tumor growth in mice [1]. Target: Others
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BTK-IN-24
Item number: TGM-T75124-10mg
Description: BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] . Target: Others
| CAS | 2649400-34-8 |
| MW: | 806.96 D |
From 357.00€
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I-152
Item number: TGM-T75128-50mg
Description: I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties [1]. Target: Others
| CAS | 311343-11-0 |
| MW: | 264.36 D |
From 198.00€
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Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br
Item number: TGM-T75130-50mg
Description: Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Br is a drug-linker conjugate for antibody-drug conjugates (ADCs), serving as a reaction reagent in the creation of anti-CD40 antibody agent conjugates [1]. Target: Drug-Linker Conjugates for ADC, Others
| CAS | 2345733-40-4 |
| MW: | 948.74 D |
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NRX-0492
Item number: TGM-T75133-50mg
Description: NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrations (DC50) of =0.2 nM and 90% degradation concentrations (DC90) of =0.5 nM....
| CAS | 2416130-57-7 |
| MW: | 817.94 D |
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MC-GGFG-AM-(10Me-11F-Camptothecin)
Item number: TGM-T75134-50mg
Description: MC-GGFG-AM-(10Me-11F-Camptothecin) serves as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 comprises a humanized IgG1 antibody linked to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a...
| CAS | 2873460-70-7 |
| MW: | 1038.04 D |
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FHD-609
Item number: TGM-T75135-50mg
Description: FHD-609, an inhibitor and degrader of BRD9 (bromodomain-containing protein 9), targets the ncBAF complex and is useful for researching a broad spectrum of cancers with mutations in a BAF complex subunit. When used alongside Telomelysin or INO5401, FHD-609 could be effective in treating adrenocortical...
| CAS | 2676211-64-4 |
| MW: | 829 D |
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IRAK degrader-1
Item number: TGM-T75136-5mg
Description: IRAK degrader-1 (example I-3) is a potent IRAK degrader [1]. Target: Others
| CAS | 2655656-99-6 |
| MW: | 871.97 D |
266.00€
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Lipid 14
Item number: TGM-T75138-2mg
Description: Lipid 14, a potent ionizable compound, is essential for synthesizing lipid nanoparticles (LNPs) [1]. Target: Others
| CAS | 2430034-05-0 |
| MW: | 907.48 D |
233.00€
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TMX1
Item number: TGM-T75139-50mg
Description: TMX1 is a molecular glue degrader that covalently targets BRD4. It selectively recruits DCAF16 to the BRD4 BD2 domain, leading to the degradation of BRD4 [1]. Target: Others
| MW: | 476.59 D |
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CPD-1224
Item number: TGM-T75140-50mg
Description: CPD-1224, an orally active derivative that binds cereblon ligands to ALK inhibitors, specifically targets and degrades EML4-ALK oncogenic fusions, including ALK and its mutants L1196M/G1202R. Target: Others
| CAS | 2891620-68-9 |
| MW: | 855.4 D |
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