Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)

Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
     
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-79982-1 100 µl - -

3 - 15 business days*

1,568.00€
BPS-79982-2 1000 µl (500 µl x 2) - -

3 - 15 business days*

10,381.00€
 
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome... more
Product information "Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)"
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. The SARS-CoV-2 Spike Pseudotyped Lentivirus (Luc-eGFP dual reporter) were produced by replacing the VSV-G fusion glycoprotein with SARS-CoV-2 Spike protein (Genbank Accession #QHD43416.1) as a surrogate viral envelope protein.. These pseudovirions also contain a firefly luciferase and eGFP cassette (Luc-P2A-eGFP) driven by a CMV promoter. The luciferase and eGFP are coexpressed under the CMV promoter in the transduced cells. Therefore, the Spike-mediated entry into the target cell can be conveniently measured via luciferase reporter activity or eGFP expression. The SARS-CoV-2 Spike pseudotyped lentivirus can be used in a cellular assay to measure the activity of neutralizing antibody against SARS-CoV-2
Keywords: 2,
Supplier: BPS Bioscience
Supplier-Nr: 79982

Properties

Application: Viral transduction mechanism studies, SARS-CoV-2 Spike, ACE2 binding neutralizing antibody screening
Species reactivity: SARS-CoV-2

Database Information

UniProt ID : P0DTC2 | Matching products
Gene ID GeneID 43740568 | Matching products

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)"
Write a review
or to review a product.
Viewed