Spike (B.1.617.2 Delta Variant) Pseudotyped Lentivirus (Luc Reporter)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-78215-1 100 µl - -

3 - 15 business days*

BPS-78215-2 1 ml (500 µl x 2) - -

3 - 15 business days*

The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome... more
Product information "Spike (B.1.617.2 Delta Variant) Pseudotyped Lentivirus (Luc Reporter)"
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. A variant called B.1.617.2 (also known as the Delta Variant) was identified in India in the spring of 2021. This variant has a number of mutations that increase morbidity and mortality and allow the virus to spread more easily and quickly than other variants. The Spike (B.1.617.2 Variant) (SARS-CoV-2) Pseudotyped Lentiviruses were produced with SARS-CoV-2 B.1.617.2 Variant Spike (Genbank Accession #QHD43416.1 with B.1.617.2 mutations, see below for details) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions contain the firefly luciferase gene driven by a CMV promoter (Figure 1), therefore, the spike-mediated cell entry can be measured via luciferase activity. The Spike (B.1.617.2 Variant) (SARS-CoV-2) pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 B.1.617.2 variant in a Biosafety Level 2 facility. Spike Mutations in B.1.617.2 Variant: T19R G142D 156/157 DELETION R158G L452R T478K D614G P681R D950N
Keywords: 2,
Supplier: BPS Bioscience
Supplier-Nr: 78215


Application: Coronavirus studies
Reactivity: Sars-cov-2

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